Nitinumap,
Are you using VSTA v 1 for your host version 1.0.0.412 and VSTA v 2 for your host version 1.0.0.721? If so you'll want to check out the Upgrade Helper. VSTA v 1 and VSTA v 2 add-ins must be loaded differently- refer to the SDK walkthroughs / samples for the loading methods. I would suggest using a different known locations to load the add-ins from.
If you are using the same version of VSTA for both host versions, then so long as you install both proxies in the GAC, the proxies are versioned, and ensure backwards compatiblitliy within the host you should be ok. Here's a related blog on using multiple host applications/proxies and a sample which demonstrates two host applications (like two versions of one host app) sharing a host ID but using different proxies.
I hope this helps, please let me know if you have any questions.
Thanks,
-Melody